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Information × Registration Number 0216U000123, 0113U001051 , R & D reports Title To study the clinical, morphological and functional features of gastroesophageal reflux disease, combined with a dysfunction of the gallbladder and the sphincter of Oddi and to identify of correction of violations. popup.stage_title Head Stepanov Yuriy Myronovych, Registration Date 21-01-2016 Organization Ukrain Research Institute of Gastroenterology Ministry of Healthcare of the Ukraine popup.description2 Object of this study was patients with Gastoesophageal reflux disease (GERD) combined with disfunction of the sphincter of Oddi and gallbladder. The aim of the study was determination of course of GERD combined wtih disfunction of gallbladder and disfunction of the sphincter of Oddi, and development of methods of increase of efficiency of therapeutic treatment of this pathology. Research methods are clinical, instrumental, biochemical, functional, imuune, morphological, statistical. It was established, that 85.0 % patients had co-morbid pathology as disfunction of gallbladder and the sphincter of Oddi. They had mainly hypokinetic and hypotonic disfunction with reduction almost twice of time of evacuation and reduction of faction of extrass. Hyperkinetic disfunctions found out at one third of patients and associated with the decline of concentration of glycocholic acid in hepatic portion of bile. Hyperkinetic disfunctions were found out at one third of patientsand associated with the decline of concentration of glycocholic acid in hepatic bile portion. The presence of disfunction of bile ducts makes the course of GERD heavier, which was confirmed рН-monitoring data. It was established that weak gastric motility increased histological signs of esophagitis. Hyperplasia of baseline layer of epidermis was revealed in 62.5 % patients. Misbalance between aggressive and protective factors of gastric juice and saliva was because of reliable increase (in 3,4 times) of the content of nitrogen oxide metabolites in gastric juice ( 84.6 % pstients) and decrease of hexosamine in saliva (63.4 % patients) Product Description popup.authors Гайдар Юрій Адольфовіч Гравіровська Ніна Геогріївна Демешкіна Лариса Вікторівна Зигало Ельвіра Вікторовна Крилова Олена Олександрівна Кушніренко Інесса Василівна Мосійчук Лідія Миколаївна Ошмянська Наталія Юрівна Парамонова Єкатеріна Володимирівна Петішко Оксана Павловна Руденко Анатолій Миколайович Степанов Юрій Миронович popup.nrat_date 2020-04-02 Close