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Information × Registration Number 0216U000290, 0115U002934 , R & D reports Title Testing of carbon-protein constructs for targeted delivery of anticancer drugs. popup.stage_title Head Sydorenko Myhail V., Registration Date 27-01-2016 Organization Department of Biotechnical Problems of Diagnostics, Institute of Problems of Cryobiology and Cryomedicine of NAS of Ukraine popup.description2 Abstract. Research report: p. 53, fig. - 5, Table. - 2, reference sources – 44. Research Facility: tumor cell line MCF-7 breast adenocarcinoma, ultra-structure carbon nanotube and diamond. The aim of the study - education prospects of using carbon materials (diamond-like carbon nanotubes), as a carrier of anticancer drugs for targeted delivery of drugs using multicellular tumor spheroid model. Research methods - methods of cell culture, cyto-morphological, MTT assay, Griess reaction, colorimetric spectroscopy. The study determined that we tested carbon nanomaterials were characterized by low cytotoxic effect (oxides), a negligible effect on the ability of cells to divide (mitotic index) and does not affect the formation of exogenous nitric oxide. In addition, we found an opportunity with the help of the UDD and BHT to stimulate the formation of multicellular tumor spheroids. Therefore, we suggest that these substances are promising for use as a biologically inert basis for drug delivery and placement of anti-tumor specific antibodies. Keywords: tumor cells are breast cancer, ultra dispersed diamond, carbon nanotubes, adhesion, proliferation. Product Description popup.authors Вдовиченко Н.О. Городна О.В. Перепелиціна Олена Михайлівна Сидоренко Михайло Васильвич Якимчук О.М. Ястребова О.В. popup.nrat_date 2020-04-02 Close