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Information × Registration Number 0216U000437, 0115U004395 , R & D reports Title Development of biocatalysts for obtaining of potential medicines: the enantiomers of 1,4-benzodiazepine-2-one derivatives and tyrosinase inhibitors. popup.stage_title Head Shesterenko Yevgeniia Arkadievna, Registration Date 04-02-2016 Organization A.V.Bogatsky Physico-Chemical Institute of the National Academy of Sciences of Ukraine popup.description2 Method of isolation of cytosolic pig liver carboxylesterase was modified, its protein-fraction composition was established. The regioselectivity of the fractions to 1- and 2- naphthyl acetate was for the first time studied. With immobilization of pig liver microsomes in agar the insoluble biocatalyst with high retention of esterase activity (90 %) was developed. It was shown the extension of pH-profile of esterase activity of the immobilized preparation to acidic and alkaline areas Product Description popup.authors Є.А. Шестеренко Ю.А. Шестеренко. popup.nrat_date 2020-04-02 Close