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Information × Registration Number 0216U000526, 0113U001282 , R & D reports Title To establish mechanisms of the premature aging at hypopinealism: chronobiological aspects popup.stage_title Head Bondarenko Lyudmiyla Oleksandrivna, Registration Date 08-02-2016 Organization State Institution "V. Danilevsky Institute for Endocrine Pathology Problems National Academy of Medical Sciences of Ukraine" popup.description2 Object of research: pineal, thyroid, pancreas, adrenal, gonads, adipose tissue, pituitary, thymus, spleen, periodontal, blood serum. Purpose: to determine the peculiarities of neuroendocrine and immune systems during prolonged hypopinealism with changes of circadian rhythms of hormonal activity of peripheral endocrine glands in the process of accelerated aging. Methods: physiological, biochemical, HRP, histological, morphometric, statistical. The work on mature rabbits who have studied the effect hypopinealism induced lighting round the clock for 10 months, On chronobiologycal features neuroimunoendocrinologycal functioning system. It was established that in 10 months. clock coverage on the background of deepening DS destructive changes in pineal gland, pituitary gland, and in the endocrine glands that underlie the formation of metabolic syndrome, hypothyroidism, and hypogonadism hypocorticism of neuroendocrine genesis. There are also signs of immunodeficiency (thymus, spleen) and periodontal disease. The above violations, coupled underlying accelerated aging and premature death. The use of replacement therapy melatonin improves the functioning of the pancreas, thyroid, thymus, adrenal and reproductive glands by strengthening hormonal activity and restore the circadian rhythm of insulin, glucose, T3, T4, testosterone, estradiol, leptin, but does not affect the morphofunctional state pineal gland, pituitary gland and spleen.Areas of application: endocrinology, pathophysiology, gerontology. Product Description popup.authors Алексєева І.І. Бондаренко Л.О. Бочарова Т.В. Бурма Т.Ю. Гєворкян А.Р. Гладких О.І. Горбач Т.В. Губіна-Вакулік Г.І. Завадська Н.В. Загуровский В.М. Карасьов М.О. Козак В.А. Лабунець І.Ф. Полторак В.В. Селюкова Н.Ю. Сергієнко Л.Ю. Соколова І.І. Сорокіна І.В. Сотник Н.М. Черевко Г.М. popup.nrat_date 2020-04-02 Close