Search academic texts

Information × Registration Number 0216U000808, 0111U010499 , R & D reports Title To develope the methods of synthesis of the new physiological active substances, derivatives of condensed, noncondensed and macroheterocyclic azolidones, to study their physical and chemical properties and biological action, to research the different kinds of western region plants to get the potential drugs, to develop technology of medicine forms of new composition and to work out the modern methodological approaches of their analysis popup.stage_title Head Zimenkovsky Borys Semenovych, Registration Date 26-02-2016 Organization Danylo Halytsky Lviv National Medical University popup.description2 The objects of investigation are newly synthesized and extracted from plant sources novel biological active substances and also substances which can be found in biological objects for national economy and medical application. With the view of the systematic targeted synthesis continuing as potential drug candidates a few series of not-mentioned in scientific chemical literature compounds were obtained including isatyn- and benzthiazolyl- substituted 4-thiazolidones, arylaminethiazolones, thiopyrano[2,3-d]thiazol-6-carboxylic acids and chromeno[4’,3’:4,5]thiopyrano[2,3-d]thiazoles. The biological activity screening of some compounds was performed. Most of these compounds were found to posses anticancer, antimicrobial, anti-inflammatory and tuberculostatic activities. The pharmacognostic and photochemical researches of a series of Western region plants were carried out and a number of biological active compounds were extracted and identified. The optimal preparation conditions were developed and pharmacological activity was studied for phyto-substances and phyto-complexes of the researched plant sources which were determined to be potentially useful for phyto-based drugs obtaining. The optimal compositions and preparation technologies were worked out for the new drugs of local action - liniments, pastes, films, gels, elixirs, sprays for using in dentistry and dermatology. The quantitative analysis methodologies for biological active compounds in substances and drugs, extraction and analysis methods of toxic substances in biological objects and environment were developed by the means of physical-chemical methods of analysis. . Product Description popup.authors Алексевич Я.І. Антонів О.І. Бензель І.Л. Бензель Л.В. Воробець Н.М. Гаврилюк І.М. Голос І.Я. Калинюк Т.Г. Піняжко О.Р. Пошивак О.Б. popup.nrat_date 2020-04-02 Close