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Information × Registration Number 0216U000861, 0113U001447 , R & D reports Title Scientific substantiation of principles, methods and indicators for experimental evaluation of the toxicity of nanoparticles and nanomaterials of heavy metals popup.stage_title Head Trachtenberg Isaak Mykhailovych, Доктор медичних наук Registration Date 03-03-2016 Organization State Institution "Institute for Occupational Health of the Academy of Medical Scieces of Ukraine" popup.description2 Experimental studies to assess the toxicity of metals nanoparticles (Fe, Cu, Fe2O3, CdS) were performed in vitro and mechanisms of their cytotoxic effect (damage to cell membranes, stimulation of oxidative stress and disturbance of metabolic processes, denaturation of proteins) and genotoxicity (damage to the nucleus and DNA) were established. Intensity of the cytotoxic effect of metal nanoparticles depended on the toxicity of the metal, the size of nanoparticles, the dose and duration of exposure. In vitro experiments on rats showed that metal nanoparticles exposure causes a general toxic effect (changes in body weight and organs); violation of the synthesis of heme, and haematopoiesis; effect on biochemical parameters characterizing the protein, lipid and carbohydrate exchanges, nonspecific natural resistance of the organism, changes in the morpho-functional state of the liver, kidneys and spleen. Based on these results the complex of methods and indicators are proposed for toxicological and epidemiological risk assessment of heavy metals nanomaterials and nanoparticles in the in vitro and in vivo, to detect the presence of potential risks associated with their production and use, depending on their physical and chemical characteristics Product Description popup.authors І.В. Губар І.М. Андрусишина І.П. Лубянова К.П. Козлов Л.А. Легкоступ Л.В. Петечел Л.М. Зайцева Н.М. Дмитруха О.Л. Апихтіна О.С. Лагутіна С.М. Дибкова Т.К. Короленко popup.nrat_date 2020-04-02 Close