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Information × Registration Number 0216U001191, 0115U004851 , R & D reports Title The development of bioactive materials for directional impact on pro- and antioxidant systems of the aging organism popup.stage_title Head Nikitchenko Yuri Victorovich, Кандидат технічних наук Registration Date 27-01-2016 Organization Kharkov National University named after V.N. Karazin popup.description2 Objects of research - physical, chemical and optical properties of nanoparticles (NPs) based on ceria (LF CeO2) ortovanadate and rare earth elements (LF GdVO4: Eu3 +), LF impact on the state of prooxidant-antioxidant system, survival and physiological indicators of aging on the body natural and accelerated aging. Methods: physical, chemical, spectrophotometry; Fluorescent spectroscopy and luminescence spectroscopy excitement; Fluorescent laser spectroscopy; Biochemical, physiological statistics. The main results and conclusions: The synthesized nanoparticles based on cerium dioxide and orthovanadats rare earth elements with different geometrical parameters and environment parameters and studied their physical and chemical characteristics. Based on these screening antiradical, antioxidant and membranе protect properties of synthesized bass woofer chosen GdVO4: Eu3 +. Prolonged use of NPs GdVO4: Eu3 + normalized prooxidant-antioxidant balance in animals with experimental accelerated aging and increased survival of old rats with natural aging. This was found to decrease rectal temperature and slowing growth in body weight of test animals. These data lead to the conclusion that GdVO4 ? Eu3 + can be the basis for the development of drugs geroprotective action or tools that can improve the quality of life of the aging body Product Description popup.authors І.Іонов В.Бондар В.Дзюба М.Асадова С.Львов popup.nrat_date 2020-04-02 Close