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Information × Registration Number 0216U001726, 0111U001202 , R & D reports Title Effect of biologically active substances of allogeneic cryopreserved placental tissue on structural and metabolic status of an organism of experimental animals under kidney insufficiency popup.stage_title Head Yurchenko Tatyana N., Registration Date 29-03-2016 Organization Institute for Problems of Cryobiology and Cryomedicine of the National Academy of Sciences of the Ukraine popup.description2 The research aim was to develop the problem of the kidney and internal organ function correction after administering biologically active substances of cryopreserved placental tissue at the background of simulated renal failure via introduction of toxic substances, as well as under autoimmune pathology conditions in rats. The research objects were a reparative regeneration of organs and metabolic changes, experimental renal failure, administration of allogenic placental cryoextract. Research methods were as follows: biochemical, histochemical, cytological, and electron microscopy. Research results. Taking a toxic kidney damage as the model we established the fact that the administration of glycerol resulted in a disorder of kidney functional indices, accompanied by anuria and oliguria, a decreased rate of glomerular filtration and increased creatinine clearance. The rat immunization caused the primary immune responses to day 21, resulting in the growth of the level of circulating immune complexes and the renal failure occurrence, the appearance of immune complexes on a basal membrane of capillaries. The cryoextract administration caused the normalization of glomerular filtration, basal membrane structure, disappearance of deposits of immune complexes, proliferation of deep cells, a decrease in endothelial dysfunction symptoms and dystrophic phenomena in the liver. Novelty, efficiency of implementation: In two models of renal failure there was first proved that the biologically active substances of allogenic cryopreserved placental tissue resulted in the normalization of kidney function indices. The placental cryoextract administration to the animals when simulating an acute renal failure was established to have an anti-inflammatory effect and delay the chronic disease phase development for 5-6 weeks. Product Description popup.authors Брусенцов Олександр Федорович Воєводченко Анжеліка Євгеніївна Жулікова Олена Павлівна Коваленко Валерій Вікторович Кондаков Ігор Ігоревич Михайлов Анатолій Миколайович Рєпін Микола Васильович Строна Віра Іванівна Шарлай Тетяна Михайлівна Юрченко Тетяна Миколаївна popup.nrat_date 2020-04-02 Close