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Information × Registration Number 0216U002349, 0115U006589 , R & D reports Title "The development of new pain drugs based on pharmacological agents that regulate the function neurospecific proton-sensitive channels" (code 03 I.1 by the State Classification of Scientific and Technical Activities DK 015-97: "Research and development in the biological sciences") popup.stage_title Head Maximyuk Oleksandr Petrovych, Registration Date 19-02-2016 Organization Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine popup.description2 As a result of the GDR а model of antagonists of the ASIC channels was founded. Antagonists of the ASIC channels can act as analgesics new pharmacological agents. In addition, ASIC channels are molecular targets against ischemic brain injury, multiple sclerosis, epilepsy and other brain pathologies. At this time there is no selective small molecules that can inhibit the activity of the ASIC channels, and thus creating new chemotype antagonists ASIC channels is an actual problem of modern pharmacology of pain and other ischemic injuries. Done electrophysiological screening of 40 names of the antagonists of the ASIC1 channels and the comparative analysis of electrophysiological and in silico screening to determine optimum farmakoforu. Research conducted by the method of "patch-clamp", which is the gold standard in pharmacology of ion channels.5481 Product Description popup.authors Єгорова Олена Володимирівна Ісаєв Дмитро Сергійович В.В.Хмиз Волкова Тетяна Михайлівна Кришталь Олег Олександрович О.П.Максимюк popup.nrat_date 2020-04-02 Close