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Information × Registration Number 0216U002455, 0113U001239 , R & D reports Title Pathogenetical conformities and information models of pathological processes development in conditions of extreme factors action upon the body and their correction popup.stage_title Head Gudyma Arsen Arsenovych, Registration Date 15-03-2016 Organization Horbachevsky Ternopil State Medical Academy popup.description2 Final report on the implementation of the scientific research work: 109 p., 20 ris., 22 tabl., 141 articles. Object of study - ischemic-necrotic cardiosclerosis, acute lung injury, chemical burn of cornea on a background of hypothyroidism, prenatal and postnatal stress, polytrauma, cranio-skeletal trauma, osteoporosis on a background of hypoestrogen, periodontitis. Aim - Determine the effect of of violations of neuro-mediator regulation processes in the heart of animals on development postishemic cardiosclerosis depending on their sensitivity to hypoxia. Identify the features of heart rate variability in acute lung injury. To study peculiarities of cornea burn injuries under the conditions previously modeled hypothyroidism and justify experiment new approaches to its correction. Determine the changes of lipid peroxidation and antioxidant protection in both sexes of rats exposed to prenatal, postnatal stress and their combinations. To study the dynamics of biliary liver function in response to skeletal, and craniocerebral, cranio-skeletal traumas during the early manifestations of traumatic disease.Evaluate the effectiveness of complex correction liver damage in experimental multiple trauma in rats. Investigate the effect of trauma on the dynamics of lipid peroxidation indexes and antioxidant cortical layer of the kidney in animals with chronic hepatitis in the early period of traumatic disease. Clarify the role of violations absorption function of the small intestine in the pathogenesis early period of skeletal, craniocerebral and multiple traumas. To study the dynamics of lipid peroxidation process violations during late manifestations of traumatic disease after cranio-skeletal traumas and efficiency of its correction by means of herbal medicine. Study the effect of of hypoestrogen osteoporosis in manifestations of cytolytic syndrome in the dynamics of the late period of traumatic disease. Establish connection between the degree of destruction of periodontal tissues and the level of pro- and anti-inflammatory cytokines, such as: IL-1?, IL-12 and IL-4 in patients with GERD depending on the mucous injury Determine the degree of pulmonary edema and metabolic rate of surfactant in the dynamics of acute lung injury hydrochloric acid. To study the relationship between serum concentrations of tumor necrosis factor-alpha and carbohydrate (cholesterol and triglycerides), lipid metabolism (glucose, insulin, leptin, adiponectin) and body mass index in experimental animals with alimentary obesity. Create a model of experimental periodontitis and assess clinical and pathomorphological changes of periodontal tissues resulting from the inflammatory process. Determine the level of lipid peroxidation in different types of experimental trauma. To analyze the leukocyte formula in rats with chronic aseptic inflammation. In this work used the following methods: electrocardiographic, experimental, biochemical, immunoenzymatic, cytological, pathomorphological, morpho metrical, mathematical and statistical. NECROTIC ISCHEMIC CARDIOSCLEROSIS, CHEMICAL BURNS OF CORNEA, HYPOTHYROIDISM, CORRECTION OF ACUTE LUNGS INJURY, POLYTRAUMA, LIVER CYTOLYSIS, SKELETAL TRAUMA, TRAUMATIC BRAIN INJURY, ASSOCIATED TRAUMA, LIPID PEROXIDATION, ANTIOXIDANT PROTECTION, BILE SECRETION, CHRONIC HEPATITIS, RENAL, HERBAL MEDICINE, OSTEOPOROSIS, PERIODONTAL DISEASE, GASTROESOPHAGEAL REFLUX DISEASE, CYTOKINES, PERIODONTITIS, INFLAMMATORY REACTION, PULMONARY EDEMA, SURFACTANT SYSTEM, DIET-INDUCED OBESITY, LEPTIN, TOTAL CHOLESTEROL, TRIGLYCERIDES. The results were published in the scientific literature. Product Description popup.authors Антонишин Ірина Володимирівна Беський Володимир Остапович Близнюк Руслан Васильович Бондаренко Юрій Іванович Гудима Арсен Арсенович Денефіль Ольга Володимирівна Кулянда Олена Олегівна Левчук Ростислав Дмитрович Лобанець Володимир Ярославович Міц Ірина Романівна Машевський Андрій Станіславович Михайлюк Ірина Андріївна Пелих Володимир Євгенович Савчук Самвел Олексійович Сатурська Ганна Степанівна Серватович Ангеліна Миколаївна Усинський Руслан Станіславович Чарнош Софія Михайлівна Юріїв Катерина Євгенівна popup.nrat_date 2020-04-02 Close