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Information × Registration Number 0216U002459, 0111U002630 , R & D reports Title Mechanisms of regulation of autophagy, stress response and synthesis of biologically active compounds in yeasts. popup.stage_title Head Sibirny Andriy Andrijovych, Registration Date 17-03-2016 Organization Institute of cell biology, National Academy of Sciences of Ukraine popup.description2 Potential protein partners of protein Atg 28 which is involved in the majority of autophagic pathways in yeast Pichia pastoris, particularly protein Atg17, which regulates activity of Atg1 and is necessary for the formation of a full-size autophagosome and a novel protein, Atg35, involved in the formation of specific MIPA-structures during micropexophagy were identified. New genes, MON1, CCZ1 and YPT7 of methylotrophic yeast P. pastoris, have been identified that are involved in pexophagy, in the pathway of transportation of hydrolases from the cytosol to the vacuole (Svt-pathway) and in nonspecific macroautophagy. Also, GSS1 gene of this yeast species encoding the glucose sensor was identified. Its deletion also leads towards pexophagy. Product Description popup.authors Борецький Юрій Романович Гринів О.Б. Дмитрук К.В. Дмитрук О.В. Куриленко О.О. Кшановська Б.В. Лизак О.О. Муращенко Л.Р. Назарко В.Ю. Назарко О.В. Пиняга Ю.В. Полупанов А.С. Семків М.В. Уженков О.С. Фаюра Л.Р. Федоренко В.О. Федорович Д.В. Чорна Д. Яковенко Г.Й. Яцишин В.Ю. popup.nrat_date 2020-04-02 Close