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Information × Registration Number 0216U002460, 0111U002630 , R & D reports Title Mechanisms of regulation of autophagy, stress response and synthesis of biologically active compounds in yeasts. popup.stage_title Head Sibirny Andriy Andrijovych, Registration Date 17-03-2016 Organization Institute of Cell Biology of National Academy of Sciences of Ukraine popup.description2 The mechanisms of response to stress caused by alcohols in methylotrophic yeast Hansenula polymorpha were investigated. A new gene ETT1 has been identified, and its deletion leads to hypersensitivity to ethanol, while overexpression, on the contrary, to the increased resistance to ethanol and elevated temperatures. The overexpression of FPS1 gene induced the increased resistance of this yeast species to ethanol and higher alcohols, in particular, to isobutanol. H. polymorpha mutants with low and high content of the tripeptide glutathione in cells were selected, which can be used for further breeding of overproducers of this tripeptide. Product Description popup.authors Борецький Ю.Р. Гринів О.Б. Дмитрук К.В. Дмитрук О.В. Красовська О.С. Куриленко О.О. Кшановська Б.В. Лизак О.О. Муращенко Л.Р. Назарко В.Ю. Назарко О.В. Пиняга Ю.В. Полупанов А.С. Рачкевич Н.О. Семків М.В. Уженков О.С. Фаюра Л.Р. Федоренко В.О. Федорович Д.В. Яцишин В.Ю. popup.nrat_date 2020-04-02 Close