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Information × Registration Number 0216U002462, 0111U002630 , R & D reports Title Mechanisms of regulation of autophagy, stress response and synthesis of biologically active compounds in yeasts. popup.stage_title Head Sibirny Andriy Andrijovych, Registration Date 17-03-2016 Organization Institute of Cell Biology of National Academy of Sciences of Ukraine popup.description2 It was found that the synthesis of riboflavin in the yeast Candida famata can be increased by modification and subsequent overexpression of PRS3 and ADE4 genes (encoding phosphoribosil pyrophosphate synthetase and phosphoribosil pyrophosphate amidotransferase, respectively) that are involved in GTP biosynthesis de novo. For the first time, we constructed recombinant strains of C. famata, which are able to overproduce a flavin nucleotide FAD without addition of expensive exogenous precursors. This was achieved by means of overexpression of FAD1 gene, encoding FAD synthetase, in the previously constructed strain that is able to overproduce other flavin nucleotide, FMN Product Description popup.authors Борецький В.Ю. Борецький Ю.Р. Гринів О.Б. Дмитрук К.В. Дмитрук О.В. Куриленко О.О. Кшановська Б.В. Левків К.О. Лизак О.О. Муращенко Л.Р. Пиняга Ю.В. Рачкевич Н.О. Семків М.В. Уженков О.С. Фаюра Л.Р. Федоренко В.О. Федорович Д.В. Юрків М. Яковенко Г.Й. Яцишин В.Ю. popup.nrat_date 2020-04-02 Close
R & D report
Mechanisms of regulation of autophagy, stress response and synthesis of biologically active compounds in yeasts.
Head: Sibirny Andriy Andrijovych. Mechanisms of regulation of autophagy, stress response and synthesis of biologically active compounds in yeasts.. (popup.stage: ). Institute of Cell Biology of National Academy of Sciences of Ukraine. № 0216U002462
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Updated: 2026-03-27


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