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Information × Registration Number 0216U002785, 0115U005737 , R & D reports Title Рreparation, screening and assessment antitoxic properties of low molecular weight substances from microalgae popup.stage_title Head Bozhkov A.I., Registration Date 18-10-2016 Organization Kharkov National University named after V.N. Karazin popup.description2 The object of study - low molecular weight components of colostrum. Experiments were carried out on male rats of 3 months old Wistar using different schemes of administration LCM and in compliance with bioethics. Purpose - to develop substances with significant biological activity. Methods - biochemical, determine the activity of glutathione peroxidase, glutathione reductase, hydroperoxides lipids, determination of glucose, cholesterol and triacylglycerides, immunological parameters. Fibrosis was induced by copper sulfate. It is shown that triple sequential administration LCM eliminates lag animals in the growth rate, eliminates expression of oxidative stress. Amid Cu-induced liver fibrosis varied content ratio of lymphocytes, neutrophils, myelocytes, metamyelocytes, eosinophils, basophils, monocytes compared with control and significantly reduced their total number. Putting animals with fibrosis LCM, accompanied by severe behavioral changes specific bone marrow cells in culture: CCM had no effect on glucose, cholesterol and ALT and AST. The results showed that LCM show a marked biological activity in models of liver fibrosis and can be used as a biological substance with hepatotropic action. Product Description popup.authors Є. Іванов А. Бондар А. Голтвянский К. Лебідь М. Асалова Н. Кургузова О. Лінкевич С. Огієнко Т. Чешко popup.nrat_date 2020-04-02 Close