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Information × Registration Number 0216U003069, 0110U000694 , R & D reports Title Molecular chaperon as a universal regulators of stress-indused signalling pathways cardiomyocytes popup.stage_title Head Sidorik L.L., Registration Date 12-01-2016 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 First studied the possible changes in the expression of both Akt1 kinase, and its phosphorylated active form (phospho-Akt1, S473) in the myocardium during the progression of heart failure by using experimental models of mice with induced heart failure (induced myocarditis CH as the first phase, and induced DСM-myocardial mice, the second, the chronic phase of heart failure). No significant changes in expression of Akt1 pathology in both cases neither the gene level or the protein level. At the same time, we found substantial and significant changes in the level of phosphorylation of Akt1 in the myocardium of mice in the final stages of progression CH (DCM-shaped disease).5481 Product Description popup.authors І.В. Крупська Бобик В.І. Вігонтіна О.Г. Капустян Л.М. Маркелова О.Ю. Рожко О.Т. Яковенко Л.Ф. popup.nrat_date 2020-04-02 Close