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Information × Registration Number 0216U003117, 0115U000265 , R & D reports Title Development of the directed drugs transport system based on physical principles of nanotechnologies popup.stage_title Head Nikolaienko Tymofii Yuriiovich, Registration Date 14-01-2016 Organization Taras Shevchenko Kiev university popup.description2 Objects of research: biotechnology of cancer treatment. Purpose - To build an integrated system of drug delivery towards predetermined areas of the body that encompases a specific protocols for nanoparticles synthesis and specific configuration of magnetic fields needed to control the transport of nanoparticles in the body. Research methods - transmission electron microscopy, dynamic light scattering, infrared absorption spectroscopy, small-angle neutron scattering, magnetic permeability measurements, computer simulations using molecular dynamics and applied quantum mechanics (quantum chemistry). Main results - the method of synthesis of liquid systems containing magnetite nanoparticles coated with organic coating with anticancer properties caused doxorubicin molecules attached to the nanoparticle surface; structural and physico-chemical studies of the synthesized liquid nanosystems; computer simulation data on the interaction of anticancer drug (doxorubicin hydrochloride) molecules with the surface of nanoparticles; development of magnetic system with permanent magnets for accumulation of ferromagnetic nanoparticles in a given area of a biological organism; development of a measurment system for determining magnetic permeability of liquid nanosystems and the method for determining the concentration of nanoparticles of magnetite in samples of liquid state of aggregation on the basis samples magnetic permeability measurements; investigation of the transport and accumulation of magnetic nanoparticles in the tumor area under the influence of a constant magnetic field under different blood circulation parameters. Publications: 4 papars and 1 abstract on an international scientific konference. The results of the research were implemented in the educational process at the Faculty of Physics of Taras Shevchenko National University of Kyiv . Liquid systems, nanoparticles, physical and chemical properties of liquid systems, intermolecular interactions, targeted drug delivery. Product Description popup.authors Голіченко Богдан Олегович Королович Володимир Феліксович Мухіна Тетяна Михайлівна Ніколаєнко Тимофій Юрійович Петренко Віктор Іванович Пилипчук Євген Володимирович Ступак Юлія Андріївна Ткачов Сергій Юрійович Черевко Костянтин Володимирович popup.nrat_date 2020-04-02 Close