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Registration Number

0216U003416, 0113U000145 , R & D reports

Title

Improve methods of diagnosis and treatment of asthma combined with allergic rhinitis in children

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Head

Antipkin Yurij, Доктор медичних наук

Registration Date

27-01-2016

Organization

State organization "Institute of pediatrics, obstetrics and gynecology NAMS of Ukraine"

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Сlinical and pathogenetic features of the formation and progression of asthma in children with concomitant allergic rhinitis were studied. It was determined that 2/3 of surveyed children with asthma combined with AR have formed by "kind of allergic march". Allergic rhinitis was found as the risk factor for severe asthma and uncontrolled diseases. Early cytomorphological marker of the presence of allergic rhinitis in children with asthma found IgE expression of nasal eosinophils. Polisensibilisation correlated with the severity asthma in children. The study of the comparative effectiveness of sublingual and subcutaneous allergen immunotherapy in children with atopic asthma combined with persistent perennial rhinitis showed that both methods allergen immunotherapy were effective and safe and had positive effect on the clinical course of asthma as well as allergic rhinitis. Low levels of IFN, high - TNF and IL-10 were determined as the immunological markers "unsatisfactory response" during sublingual Immunotherapy in children with asthma combined with allergic rhinitis. Different individual schemes of allergen immunotherapy for children with asthma combined with allergic rhinitis are proposed to medical practice. It depends on presentation the detected immunological markers of "unsatisfactory response" to allergen immunotherapy.

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І. Лук'янова
А.Наконечна
В. Лапшин
В.Чернишов
К.Несвітайлова
Л. Вербицька
Л. Степанова
Н. Нетреба
Н. Чумаченко
О. Смирнова
О. Толкач
О.Марчук
С. Матвєєва
С. Нєдєльська
Т. Задорожна
Т. Кондратенкова
Т. Уманець
Т.Гришина
Т.Лисяна
Ю. Антипкін

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2020-04-02