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Registration Number

0216U003550, 0113U002328 , R & D reports

Title

Identification of association between diabetes mellitus and non-cancer thyroid disease in CHNPP accident survivors

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Head

Kaminsky Oleksij Valentinovich, Доктор медичних наук

Registration Date

01-02-2016

Organization

State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine "

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The object of study is a retrospective assessment of data on 24,588 adults and 20,087 children who had survived after the Chernobyl accident from database of the Clinical and Epidemiological Registry (CER) NRCRM for 23 years (1992-2014 period ). Subjects were healthy or had a varied range of endocrine diseases. Among the surveyed adults there were liquidators (n=10798), evacuees from the 30 km exclusion zone (n=7144), and residents of contaminated areas (n=5385). The average external exposure dose was 0.187 Gy for adults, identified thyroid radiation dose in children was within 0,1-1,55 Gy. The verified clinical data were obtained through the check-up of outpatients or inpatients. The 497 persons and their descendants (43 children) were examined in a clinical setting. The control group included 73 persons of adult age and 15 children from the general population of Ukraine (uninvolved in the Chernobyl accident). The objective of the study - to investigate the clinical and pathogenetic links between diabetes mellitus (type 1 and 2, latent autoimmune diabetes of adults "LADA") and non-malignant thyroid disease in survivors of the Chernobyl accident in the remote post-accident period. Methods: the generally accepted clinical, anthropometric (weight, height, body mass index), instrumental (blood pressure, ECG, thyroid ultrasound), laboratory (biochemical, hormonal), and data statistical review. In the course of research for the first time it was found that the occurrence of thyroid disease depends on pathological hormonal disorders that accompany the pereddiabetes/type 2 diabetes mellitus and preobesity/ obesity. The development of insulin resistance, hyperinsulinemia and basal leptin resistance accompanied by an increase in the frequency of all classes of thyroid disease, especially in people who survived after the Chernobyl accident been exposed to ionizing radiation in range of external doses of 0.1-0.7 Gy. It has been established that manifestation of the ionizing radiation effect on some branches of endocrine system in the Chernobyl accident survivors took place over the 15-25 years, which was accompanied by substantial and significant (p<0.01) increase in the frequency of non-malignant thyroid disease, diabetes, obesity and metabolic syndrome, which had a strong tendency to further growth. Children, evacuated from a 30-km exclusion zone and been irradiated at the age of 3-6 years are a critical group. The revealed relationship between functional state of pancreatic beta cells and development of benign hypertrophic and hyperplastic processes in thyroid is realized by the dysfunction of these cells, basal hyperinsulinemia, insulin resistance, with increased body weight. The extent of implementation - the 34 scientific works are published, including 5 of them abroad, 14 presentations were made at conferences, including 5 of them abroad. Field of application - radiation medicine, clinical endocrinology.

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Єгорова Ірина Вікторівна
Афанасьєв Дмитро Євгенович
Ваколюк Катерина Олександрівна
Камінський Олексій Валентинович
Копилова Ольга Василівна
Муравйова Ірина Миколаїна
Пронін Олексій Володимирович
Чикалова Ірина Григорівна
Яніна Антоніна Миколаївна

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2020-04-02