Search academic texts

Information × Registration Number 0216U003789, 0111U007664 , R & D reports Title Physico-chemical mechanisms of the living functioning at the different levels of the organization. popup.stage_title Head Korneliuk Oleksandr, Registration Date 16-02-2016 Organization Taras Shevchenko Kiev university popup.description2 Object of study: biopolymers, components of nucleic acids and proteins and their complexes, biologically active compounds are broad-spectrum, structural mechanisms therapeutically important macromolecules interactions with each other and with potential drugs, microorganisms, electromagnetic radiation, substance nanoscale sizes. Objective: a complex of modern methods to determine the general physical and chemical laws that underlie the functioning of living systems, biopolymers and their complexes, spatial structure and molecular dynamics, created on the basis of biologically active compounds with a broad spectrum of activity, enzyme inhibitors - potential diagnostic and medicines, to investigate the effect of substances of different origins, chemical and physical factors of electromagnetic fields on living objects. Methods: Bioinformatic, physical, chemical, biochemical, biotechnology, computer modeling. As a result of the research stages, received the following main results. The mechanisms of exogenous physical and chemical factors on the spatial structure of biopolymers, established the basic physical and chemical mechanisms of point mutations caused tautomerisation DNA bases; investigated the conformational capacity of modified nucleosides and compared its performance with canonical nucleosides; defined electronic topological and geometrical characteristics and functional significance of hydrogen bonds in macromolecules; spatial structure MtTyrRS received and analyzed the functional role of amino acid residues in the active centers; The dynamics of the active center of the enzyme and the conformational mobility of the important amino acid residues in its active center. Product Description popup.authors Броварець О. Говорун Д. Дзядзевич С. Дудченко О. Корнелюк О. Мацишин М. Микуляк В. Пєшкова В. Плоднік Д. Солдаткін О. Солдаткін О. Старосила С. Степурська К. Цимбалюк О. popup.nrat_date 2020-04-02 Close