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Registration Number

0216U003886, 0112U004714 , R & D reports

Title

Antitumor photodynamic activity of composite photosensitizers based on surface-plasmon resonance nanoparticles

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Head

Gamaleia Mykola Fedorovych,

Registration Date

23-02-2016

Organization

R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology

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The complexes of photosensitizer chlorine e6 and gold nanoparticles (GNPs) with different geometrical characteristics were synthesized. In experiments on malignant cell cultures it was found that chlorine e6 conjugation with GNPs increases the photodynamic activity of photosensitizer. For nanocomposite that contained GNPs stabilized by dextran-polyacrylamide copolymer (D-PAA), effectiveness raised up to two times. Photodynamic therapy of mice with Lewis carcinoma showed that application of photosensitizer composites with gold nanoprisms or D-PAA stabilized GNPs, lead to inhibition of tumor growth by 50-60% comparatively to therapy with free chlorin e6. Based on conducted research, chlorine e6 composite with D-PAA stabilized GNPs is recommended for advanced preclinical study.

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Гамалія М.Ф.
Долинський Г.А.
Завадська Т.С.
Прокопенко І.В.
Шишко Є.Д.
Штонь І.О.

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2020-04-02