Search academic texts

Information × Registration Number 0216U003925, 0112U004720 , R & D reports Title Study of the inhibition mechanisms of malignant tumor growth and metastasis by some modifiers of energy metabolism popup.stage_title Head Solyanik Galina Ivanivna, Registration Date 24-02-2016 Organization R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology popup.description2 It was shown that dichloroacetate (DCA) in a wide concentration range did not stimulate the production of reactive oxygen species (ROS) by cancer cells and did not induce apoptosis. DCA anticancer action was realized predominantly due to it cytostatic activity rather than cytotoxic one. It was proved that anticancer efficacy of DCA and 2-deoxy-D-glucose considerably depended on drug input schedule and was increased under prolong metronomic administration. Despite an insignificant influence on tumor growth DCA displayed high antimetastatic activity against Lewis lung carcinoma. It was revealed that DCA antitumor effect was directly correlated with an ability of this agent to enhance cytotoxic function of tumor associated macrophages via increase of ROS production by these phagocytic cells. Product Description popup.authors Горбик Г.В. Дасюкевич О.Й. Колесник Д.Л. Прохорова І.В. Пясковська О.М. Соляник Г.І. Тарасов О.С. Федорчук О.Г. Хаєцький І.К. Якшибаєва Ю.Р. popup.nrat_date 2020-04-02 Close