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Information × Registration Number 0216U003974, 0115U001404 , R & D reports Title Development of the system of fast screening of DNA-binding compounds for the search of inhibitors of nucleic acids biosynthesis enzymes as potential antitumor and antimicrobial agents popup.stage_title Head Dubey Igor, Доктор хімічних наук Registration Date 03-03-2016 Organization Institute of Molecular Biology and Genetics popup.description2 The conditions of use of the series of intercalating and non-intercalating dyes in FID (Fluorescent Intercalator Displacement) assay were studied. Optimal conditions of the screening (dye type, dye/DNA ratio, optical filters) in manual and automatic format were found. Binding parameters of a number of new efficient topoisomerase and telomerase inhibitors of various classes with duplex and quadruplex DNA were determined, high interaction affinity was demonstrated. Product Description popup.authors Ільченко Микола Миколайович Алексєхєва Інна Володимирівна Дубей Лариса Василівна Костіна Валентина Григорівна Костенко Олександр Миколайович Криворотенко Дмитро Валентинович Кузів Ярослав Богданович Негруцька Валентина Володимирівна popup.nrat_date 2020-04-02 Close
R & D report
Development of the system of fast screening of DNA-binding compounds for the search of inhibitors of nucleic acids biosynthesis enzymes as potential antitumor and antimicrobial agents
Head: Dubey Igor. Development of the system of fast screening of DNA-binding compounds for the search of inhibitors of nucleic acids biosynthesis enzymes as potential antitumor and antimicrobial agents. (popup.stage: ). Institute of Molecular Biology and Genetics. № 0216U003974
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Updated: 2026-03-23


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