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Information × Registration Number 0216U005003, 0115U004747 , R & D reports Title Application of N-acylethanolamines as new antistress drugs with adaptogenic properties popup.stage_title Head Gula Nadiiya Maksymivna, Registration Date 11-01-2016 Organization A.V.Palladin Institute of Biochemistry of National Academy of Sciences popup.description2 The object of study - the water suspension of N-stearoylethanolamine. The aim of the study - to develop a new drug with anti-stress and adaptogenic action based on N-acylethanolamines. Research methods - biochemical, spectrophotometric, immunoenzymatic, physiological, statistics. The report presents scientific data of N-stearoylethanolamine anti-stress properties. In this study we recreated the model of chronic social stress in rats and investigated the influence of N-stearoylethanolamine on behavioral reactions of animals, as well as a number of biochemical indices in rats in conditions of chronic stress. It was found that a two-week social stress inhibits the physiological rate of weight loss with age and causes the development of stress-induced analgesia. At the behavioral level, stress is manifested in the enhanced number of grooming and the increase of locomotor and exploratory activity in the open field. The application of NSE on the background of chronic stress increases the adaptive capacity of the body, causing an increase in rat plasma the level of corticosterone - hormone responsible for the body's response to the action of stress factors. It was found that the impact of NSE on sympathoadrenal system of animals with chronic stress is manifested in the modulation of catecholamine content in rat plasma, namely the normalization of adrenaline, dopamine and the prevention of norepinephrine reduction in animals with subordinate status (status of "loser"). Application of NSE under chronic social stress leads to a decrease in plasma testosterone level in rats with subordinate status that indicates a decrease in the identification of aggressive behavior. It was shown that NSE prevents changes of redox processes in rat plasma, caused by the influence of chronic stress. It was revealed that the NSE prevents a decline in rat plasma content of nitric oxide stable metabolite - nitrite anion induced by the action of chronic social stress. The results of physiological studies have shown that the use of NSE on the background of social stress modifies the behavioral consequences of stress, reduce the appearance of stress in behavioral tests. Meanwhile NSE prevents stress-induced analgesia in rats exposed agonistic social interactions. Thus, the results indicate a pronounced adaptogenic and anti-stress effect of NSE that can be used as a basis for creating a new generation of drug with adaptogenic action to eliminate the negative effects of social and other kinds of stress on the human body. Keywords: N-STEAROYLETHANOLAMINE, CHRONIC SOCIAL STRESS, GLUCOCORTICOIDS, CATECHOLAMINE, TESTOSTERONE, NITRIC OXIDE, BEHAVIORAL RESPONSE OF RATS, STRESS-INDUCED ANALGESIA Product Description popup.authors Асмолкова В.С. Бердишев А.Г. Бондаренко О.В. Горідько Т.М. Гудзь Є.А. Гула Н.М. Коваленко О.А. Косякова Г.В. Лозова В.М. Макарчук М.Ю. Онопченко О.В. Тубальцева І.І. Тукаленко Є.В. popup.nrat_date 2020-04-02 Close