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Information × Registration Number 0216U005211, 0114U003531 , R & D reports Title development of fundamental physico-chemical foundations of a new vector substance systems for antitrumor drugs and creating technological requirements of its production popup.stage_title Head Gorbyk P.P., Доктор фізико-математичних наук Registration Date 20-01-2016 Organization Institute of Surface Chemistry of the National Academy of Sciences of Ukraine popup.description2 Object of study - nanochemical nanopowder synthesis processes of magnetosensitive nanomaterials and nanocomposites with biocompatible coating; stabilization, modification and study the properties of nanocomposites; physical and chemical processes for obtaining of magnetic fluids containing nanocomposites functionalized with cytostatics; optimization of physico-chemical process of manufacturing new pharmaceutical form based on standardized substance vector systems of anticancer drugs. The aim for stage 2 (03.2015 - 12.2015 g.) is to develop the scientific basis of magnetic fluid with cytotoxic properties (model of new pharmaceutical form) based on a standardized vector system substance of anticancer drugs. Research methods - X-ray analysis, electron microscopy, IR spectroscopy, vibration magnetometry, spectrophotometry, measurement of specific surface area by nitrogen adsorption more. Research aimed at developing scientific approaches to creating a new substance vector systems based on magnetic fluids containing modern anticancer therapy drugs, establishing the principles of optimization and standardization of parameters for practical use in the form of new dosage forms and preparation of mass production of the domestic production. It was established that the vector system based on magnetic fluids and cisplatin improves the therapeutic effect due to higher antitumor activity against resistant tumors and tumor selective accumulation in the fire and prevent toxic cytostatic influence on the body as a whole (with IEPOR named after R.E. Kavetsky). The results form the physico-chemical basis for the creation, production and introduction into clinical practice of new national cancer cytotoxic drug forms. Experimental results show perspective for further studies of obtained nanocomposites by means of photodynamic therapy of cancer method. The investigations in 2015 published 11 scientific papers: articles - 5, abstracts - 5 patents - 1. List of works presented in the Appendix.KEYWORDS: NANOSIZED MAGNETITE, SURFACE MODIFICATION, CYTOSTATICS, MAGNETOSENSITIVE NANOCOMPOSITES, VECTOR SUBSTANCE SYSTEMS FOR ANTITRUMOR DRUGS Product Description popup.authors Є.В. Пилипчук А.Л. Петрановська Горбик Петро Петрович М.В. Абрамов О.А. Васильєва С.П. Туранська popup.nrat_date 2020-04-02 Close