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Information × Registration Number 0216U005253, 0113U003034 , R & D reports Title Nanoliposomes and solid nanoparticles loaded with the Rhenium-Platinum system in models of hepato-, nephro-pathies and hemolytic anemias popup.stage_title Head Dyomshina Olga Alexandrovna, Registration Date 21-01-2016 Organization Dniepropetrovsk national university popup.description2 Research object - hepato-, nephro-protective, antitumor, anti hemolytic and antioxidant effects of cluster compounds of rhenium with ligands - biologically active derivatives of carboxylic acids and of different configuration (cis-, trans- near quaternary bond) upon introduction of compounds of rhenium and antitumor platinum-rhenium system in experimental models in rats; nanoliposoms formation and solid nanoparticles containing a rhenium compound, and cisplatin. A purpose is development of fundamental bases of biochemistry, in particular such directions as study of molecular mechanisms of pathological processes and ways of their correction; impact study of anti-tumor platinum-rhenium system developed as nanoliposom and solid nanoparticles with rhenium compounds of various structures on the liver, kidneys and red blood system in models of pathologies in rats with impaired redox status; development of new drugs and therapeutic methods based on organometallic compounds. Research methods are conventional biochemical, morphological, histological and mathematical statistics. It is found first time that a system based on rhenium compounds, which, along with anti-cancer properties has the property to stabilize the system of red blood cells, hepatocytes and nephrons, and gives a unique effect of inhibition of carcinogenesis. The effect of nanostructured forms of rhenium compound on the enzyme activity of cells and blood plasma is determined, which makes it possible to use these parameters as an additional diagnostic status parameter organism under correction of pathological condition. Industries of application are biochemistry, biophysics, physiology, pharmacology. The users of results - scientific establishments, higher educational ones which carry out research and/or educational process in indicated and contiguous industries are possible. Product Description popup.authors Антропов Сергій Миколайович Бабій Світлана Олександрівна Воронкова Юлія Сергіївна Дьомшина Ольга Олександрівна Леус Інга Володимирівна Магро Лариса Алимівна Садовська Олена Федірівна Семенов Сергій С Шамелашвілі Карина Володимирівна Штеменко Наталія Іванівна popup.nrat_date 2020-04-02 Close