Search academic texts

Information × Registration Number 0216U005255, 0113U003036 , R & D reports Title Directed synthesis of biologically important heterocyclic and open heteroatomic structures based on commercially available dienes popup.stage_title Head Okovytyy Sergiy Ivanovich, Registration Date 21-01-2016 Organization Dniepropetrovsk national university popup.description2 A convenient preparative methods of new aminoalcohols and sulfonamides synthesis involving amines of norbornene, adamantane, norbornane and epoxysulfolanes rows have been developed. The complex spectral study aimed to investigate stereochemical features of obtained herein structures have been performed.The methods of aminoalcohols functionalization based on investigation of alternative reaction centers have been developed. It has been shown that "domino-aminolysis of diepoxides" can be considered as a new strategy of azapolycyclic compounds synthesis. New derivatives of nitrogen containing heterocycles have been obtained due to applying of aforementioned procedure. The investigation of reduction reaction for epoxynorbornane by sodium borohydride have been done. The biological activity (analgesic, anticonvulsant, tranquilizing, anti-hypoxic, anti-inflammatory) and toxicity of synthesized compounds have been investigated. In several cases the dependence of biological effects on structural and electronic factors have been established. Obtained results could be applied in the process of drug design, synthesis of polymeric compositions with valuable properties, solving problems of theoretical and experimental organic chemistry.Application: synthetic organic chemistry, pharmaceutical chemistry, agriculture. Product Description popup.authors Гапонов Олександр Олексійович Заровна Ірина Сергіївна Пальчиков Віталій Олександрович Сергеєва Тетяна Сергеєва Середюк Володимир Олександрович popup.nrat_date 2020-04-02 Close