Search academic texts

Information × Registration Number 0216U005289, 0115U002699 , R & D reports Title The study of the incorporated -131I influence on the endocrine system in the first and second generations (experimental and clinical research). popup.stage_title Head Derevyanko Ludmyla Petrivna; Tal'ko Viktoriya Vasylivna, Registration Date 21-01-2016 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Object (experiment) - functional state of the pituitary-thyroid and pituitary-gonadal systems in mature white laboratory rats of both sexes, pro- antioxidant system, the concentration of glucose in the blood, peripheral blood parameters; clinical observations - the structure of identified thyroid diseases and other. systems. Objective: To investigate the functional state of the pituitary-thyroid and pituitary-gonadal system in rats born to the first generations of animals irradiated incorporated the I-131, to determine the state of the pituitary-thyroid system in children born from parents exposed to irradiation . Methods (experiment): the concentration of T3, T4, TSH, estradiol, testosterone, TBK-active products, SOD , blood glucose concentration (56 animals, 8 experimental groups). Methods: clinical, anthropometric (weight, height, body mass index), instrumental (ultrasound of the thyroid gland), laboratory (biochemical, hormonal, immunological) statistics. The experiment produced evidence discoordination regulatory function of endocrine system. Designed studies of thyroid state and data of somatic-sexual development of children born to exposed parents, for the formation of the priority groups with different endocrine patolog. A retrospective analysis of diseases, revealed in 2155 children aged 10-16 years, born from irradiated parents (2010-2014 pp.). The study included 35 children, established that the children of the first generation born from irradiated parents constitute a priority group of long-term observation. Product Description popup.authors Атаманюк Н.П. Дерев'янко Л.П. Кондратова Ю.А. Копилова О.В. Плескач О.Я. Прохорова Є.М. Талько В.В. popup.nrat_date 2020-04-02 Close