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Information × Registration Number 0216U005431, 0113U001290 , R & D reports Title To explore the endocrine mechanisms of alcohol dependence. popup.stage_title Head Minko A.I., Registration Date 06-07-2016 Organization State Institution " Institute neurology, psychiatry and narcology AMS of Ukraine" popup.description2 Objects of research are the mechanisms of alcohol dependence, burdened by the consequences of perinatal pathology and endocrine disorders. Our purpose was to study the endocrine mechanisms of formation of alcohol dependence in teenagers with the consequences of organic brain damage. Methods of research were the following: clinical and anamnestic, clinical, psychopathological, psychodiagnostic, biochemical, electrophysiological, anthropometrical and method of mathematical statistics. It was established that the formation of alcohol dependence in adolescence occurs on the background and with the participation of negative consequences of early organic lesions of central nervous system, physiological pubertal increase of the male sex hormone (testosterone levels), as well as increase of the leading stress hormone cortisol, that creates a biological basis for the development of the state "hard adaptation" and raises interest for the use of alcohol. However, the levels of testosterone in the blood of adolescents do not achieve their normal age-related values responsible for the low rate and the anomalous character of somatic-puberty process, i.e. dysontogenesis. Chronic alcohol intoxication decreases the levels of testosterone and cortisol, and thus the severity of the stress reaction, which creates biological testosterone-cortisol mechanism of fixing of alcohol dependence state. Product Description popup.authors Єна Р. Артемчук А. Бараненко О. Болотов О. Гольцова С. Лісна Н. Лобанов І. Мінко О. Чалиш І. Шалашов В. popup.nrat_date 2020-04-02 Close