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Registration Number

0216U005598, 0111U000473 , R & D reports

Title

To study molecular genetic and immunobiological properties of rabies virus isolates that are circulating at the territory of Ukraine, and their correspondence to vaccine strains

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Head

Polupan Ivan M.,

Registration Date

05-02-2016

Organization

The Institute of veterinary medicine of Ukrainian Academy of Agrarian Sciences

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We conducted phylogenetic analysis of the sequence of sections N- and G-gene of rabies virus. Found two genetic clusters of rabies virus in Ukraine, who belong to the first genotype of lissavirus and differ among themselves by 2-3%. Established that all vaccine strains of rabies virus (SAD 19, SAD 5/88 and SAD Bern) are groups of PV but test specimens belonging to other cluster. With ArcGIS 10.0 program was modeled geographic distribution of rabies virus genetic clusters for N- and G-genes on Ukraine map. We revealed a cluster circulation in Khmelnytsky region corresponding to map the prevalence of rabies in Ukraine. Established that the protection of "rabies immunoglobulin" and four commercial rabies vaccines less effective (in 1,5-3,5 times) against the street rabies virus isolates belonging to the genetic clusters B, in comparison with isolates belonging to the genetic cluster A. This is one of reasons of high rabies prevalence in territory of regions where established genetic cluster B circulation. Designed serological method of evaluation potency immunogenic inactivated rabies vaccine, which is patented in Ukraine. Developed three scientific and methodological developments and monograph which approved by the State Veterinary and Phytosanitary Service of Ukraine.

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Нікітова Аліна Петрівна
Полупан Іван Миколайович

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2020-04-02