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Information × Registration Number 0216U006210, 0111U006155 , R & D reports Title To elaborate methods of stabilization of activity of gonadotropic hormonal preparations and to study mechanisms of their influence on the realization of the reproductive function of farm animals. popup.stage_title Head Gevkan Ivan Ivanovych, Registration Date 16-02-2016 Organization Institute of animal biology Ukrainian academy of agrarion popup.description2 Studied various stabilizing substances: sugars, amino acids and complex combination of gonadotropins for saving activity developed best practices for stabilization дanodotropins and methodological approaches to the creation of new forms of drugs based on stabilized gonadotropins in the form of liposomal emulsions and studied their activity in conditions of prolonged storage. Established that the dispersion leads to loss of 10-12% of the activity gonadotropin however, dispersion length does not affect its activity. As a result of studies found that we added stabilizers and liposomal drug form the conservation gonadotropin activity during long-term storage at a temperature of 18-20 ° C and about 2-4 at 80%. Introduction stabilized gonadotrophin preparations during artificial insemination femail rabbits has an effective impact on their reproductive function and causes increased activity of lactate dehydrogenase, progesterone and estradiol concentrations in serum rabbit. Injection 1000 IU us gonadotropine stabilized drug during artificial insemination of cows increases the number of fertilized cows doubled compared to a group of cows in which it did not apply. Effective action stabilized liposomal drug gonadotropine confirmed increased activity and lactate concentrations of progesterone and estradiol in the blood serum of cows within one hour after its introduction and artificial insemination, and the increased activity and lactate concentrations of estradiol and progesterone on day 10 after fertilization stimulation indicates embrionalno- uterine interactions and effective embryo implantation and insemination. Product Description popup.authors Сирватка В. Я. Сливчук Ю. І. Штапенко О. В. popup.nrat_date 2020-04-02 Close