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Information × Registration Number 0216U007097, 0113U001661 , R & D reports Title Experimental and clinical background of optimization of treatment of patients with age-related macular degeneration popup.stage_title Head Pasyechnikova Natalya V., Registration Date 05-04-2016 Organization The Filatov Research Institute of Diseases and Tissue Therapy popup.description2 The results and their novelty: The femtosecond laser radiation with a wavelength of 800 nm and high pulse repetition frequency (76 MHz) in addition to the effect of cavitation in tissues causes phenomenon of thermal damage to the structure of the retina, mainly photoreceptor layer and retinal pigment epithelium. Micropulse laser radiation with a wavelength of 577 nm causes ultrastructural changes in the retinal pigment epithelium, without affecting the integrity of the chorioretinal complex anatomy. For the first time found that all patients with wet age-related macular degeneration impaired ocular circulation as 68% of blood flow disturbance of choriocapillaries and macular area, indicating that the pathogenetic significance of circulatory disorders in this disease. In peripheral blood and in the vitreous of rats defined erythropoietin concentrations (26,2 ± 1,4) pg/ml (21.8 ± 331.6) pg/ml, respectively. Enhanced scientific evidence of pathological changes in the retina of rabbits after three consecutive injections of angiogenesis inhibitors revealed destruction of pigment epithelial cells and photoreceptors; vacuolization, karyorrhexis, karyopyknosis of ganglion cells, especially after the first injection of bevacizumab and only after the third injection of ranibizumab and pegaptanib sodium. Enhanced scientific evidence about the semi-quantitative assessment of histomorphological ocular changes in bacterial staphylococcal endophthalmitis and their normalizing after combined use of antimicrobial photodynamic therapy with 0.1% methylene blue. For the first time found that complete regress of serous retinal pigment epithelium detachment occurs in 37% after treatment with triamcinolone acetonide independently of the way of administration. Product Description popup.authors А.О. Невська Головченко В.Г. Гончаренко Л.В. Думброва Н.Є. Задорожний Олег Сергійович Кацан Сергій Володимирович Король Андрій Ростиславович Кустрин Тарас Богданович Міхейцева І.М. Молчанюк Н.І. Насінник Ілля Олегович Науменко Володимир Олександрович Пасєчнікова Наталія Володимирівна Пилькевич Т.С. Рябчун О.В. Стоцька Л.М. Терлецька О.Ю. Федченко С.О. Храменко Н.І. Чорнобай М.О. popup.nrat_date 2020-04-02 Close