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Information × Registration Number 0216U007404, 0111U010177 , R & D reports Title Development and study of medications with anti-inflammatory and reparative activity based on regional natural raw materials popup.stage_title Head Rozhkovsky Yaroslav Volodimirovich, Registration Date 28-11-2016 Organization Odesa National Medical University popup.description2 It has been shown that the ointment form of the drug "Marepolimiel" based on PEG-400 : PEG-1500 containing 50% of complex minerals of sea water, has a distinct anti-inflammatory activity in models karragenine, histamine, serotonin edema and more distinct reparative properties of uninfected and infected models of linear and planar wound and burn wound skin in rats compared with reference drug - ointment "Vulnuzan." It has been established that the wound-healing mechanisms of ointment "Marepolimiel" are associated with the activation of microcirculatory processes in the area of traumatic injury, stimulation of protein synthesis by liver, together with antioxidant, and membraneprotective, anticytolitic properties, normalization of protein, nitrogen metabolism, decrease levels of endogenous intoxication and immunocorrective effect, positive effect on the process of wound healing in the early stages after reproduction. In acute and chronic experiments in the ointment "Marepolimiel" no evidence of toxic and locally irritating action has been found. Product Description popup.authors Анісімов Володимир Юрійович Гельмбольдт Володимир Олегович Кливняк Богдан Михайлович Ковальчук Ірина Вікторівна Ложичевська Ірина Вікторівна Ложичевська Тетяна Вікторівна Нікітін Олексій Володимирович Образенко Майя Сергіївна Осійчук Ольга Володимирівна Приступа Богдан Володимирович Разкевич Олеся Степанівна Рожковський Ярослав Володимирович Стручаєва Галина Іллівна Сущук Наталя Анатоліївна Улізко Ігор Володимирович Фізор Наталя Селіверстівна popup.nrat_date 2020-04-02 Close