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Registration Number

0216U007409, 0114U000774 , R & D reports

Title

The role of epigenetic modification of Wnt gene regulatory pathways (GHSR, TUSC5, WIF1, DKK4 and SFRP5) in the differential diagnosis of hyperproliferative and neoplastic processes of breast and uterus.

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Head

Zaporozhan Valery Nikolaevich,

Registration Date

28-11-2016

Organization

Odesa National Medical University

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investigated level of methylation of genes GHSR, DKK4, SFRP5 and TUSC5 a biomarker for the differential diagnosis of hyperproliferative diseases and cancer of the endometrium. As a result of this work proved significant difference between the content of DNA methylation genes GHSR, TUSC5 and SFRP5 in breast cancer tissue samples and endometrium compared with benign tissue and normal tissue of breast and endometrium. Promoter methylation and gene WIF1 DKK4 in breast cancer tissue samples compared to normal and benign processes breast tissue was also significant. The methylation of gene promoters and WIF1 DKK4 in the samples compared with benign processes endometrial tissue of endometrial cancer and normal endometrial tissue was not significant. In additional studies it was shown significant difference content of methylated DNA in gene SFRP2 tissue samples of endometrial cancer in comparison with benign endometrial tissue and normal endometrium.

Product Description

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Бубнов Владимир Вячеславович
Запорожан Валерий Николаевич
Маричереда Валерія Генадієвна
Поклад Ганна Георгіевна

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2020-04-02