Search academic texts

Information × Registration Number 0216U007570, 0115U005146 , R & D reports Title Synthesis of fluorinated nitrogen- and sulfur-containing heterocycles via cycloaddition of 1,3-dipoles to polyfluoroalkanethiocarboxylic acid amides popup.stage_title Head Mykhaylychenko Sergiy Sergiyovych, Registration Date 22-12-2016 Organization Institute of Organic Chemistry National Academy of Sciences of the Ukraine popup.description2 This work is devoted to the investigation of new reactions of amides of polyfluoroalkanethiocarboxylic acids with various 1,3-dipoles and the study of their synthetic possibilities. Azomethine ylide, nitrile imines and nitrile oxide were used as 1,3-dipoles, which were generated in situ. The effects of the structural factors (substituents at the nitrogen atom of thioamides and a length of the polyfluoroalkyl substituent) on the proceeding of the reactions were studied. New and convenient methods for the synthesis of fluorinated 1,3-thiazolidines and 1,3,4-thiadiazolines were developed. The obtained heterocyclic compounds are promising subjects for the investigations in the field of modern medicinal chemistry and may found application in the rational design of biologically active substances. Product Description popup.authors Михайличенко Сергій Сергійович popup.nrat_date 2020-04-02 Close