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Information × Registration Number 0216U008081, 0111U008364 , R & D reports Title Regulation of excitability of neurons in mammalian peptide molecules of endogenous and exogenous origin popup.stage_title Head Kryshtal Oleg О., Доктор біологічних наук Registration Date 17-06-2016 Organization International center of molecular physiology popup.description2 Main sensors of ATP is superfamily purinergic ionotropic Р2Х and metabotropic Р2У receptors. Р2Х receptors are activated by ATP and are involved in the control of visceral activity and noscapine transmission of signals from the periphery to the Central nervous system. The knotty ganglia neurons that collect sensory information from internal organs widely Express how Р2Х and range of G-protein paired receptors. However, currently little information on regulation of the activity Р2Х3 metabotropnye receptors G-protein coupled receptors, including opioid receptors (µ,?,K.). A comparative analysis of the modulation of endogenous receptors Р2Х3 opoa Leoncavallo neurons in the dorsal and knotty ganglia (VG and DG). It is established that Р2Х3 receptors in neurons of the DG are more sensitive to Leoncavallo comparison with receptors of the neurons of the ganglion nodosum. This is indicated by the concentration dependence of the inhibition. It was found that modulation of activity fully mediated by activation of opioid receptors as a competitive antagonist of opioid receptors naloxone has removed the oppression. Applied the Protocol for the study of antagonist-induced regulation of opioid sensitivity shows different steps in the neurons of the DG and VG. It is established that short-term prankplace of DG neurons with naloxone enhances the inhibitory effect of the LEK, whereas prankplace neurons of the SH does not change opioid sensitivity. These observations suggest that modulation of the final targets opoae neurons in the DG and VG are different specific intracellular path. Product Description popup.authors Волкова Т.М. Максимюк О.П. Хмиз В.В. Чіжмаков І.В. popup.nrat_date 2020-04-02 Close