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Information × Registration Number 0216U008211, 0116U001002 , R & D reports Title The research of the cryosensitivity and the factors of the resistance reduction of the umbilical cord blood cellular components to the freezing factors at the temperature of the liquid nitrogen. popup.stage_title Head Kalynychenko T.O., Доктор медичних наук Registration Date 15-12-2016 Organization Kiev Research Institute of Haematolojy and Blood Transfusion popup.description2 Research object: cord blood nuclear cells, cord blood red cell concentrate. Methods: сryobiological, morphological, biochemical, cultural, immunohematological. The average values cryosensitivity of umbilical cord blood hematopoietic tissues have been mounted on the condition of the slow freezing and under the protection of the substances, which have different mechanisms of action and depending on the definite storage time after delivery at the room temperature (for one or two days). We have shown that high levels of the cord blood nuclear cell cryosensitivi ty have been linked to those of the lipid peroxidation molecular products, especially the phospholipids. The links between declining indicators of the cell cryo resistance and structural and functional disorders in their membranes as a consequence of the activation of the peroxidation processes of the neutral lipids and the phospholipids have been confirmed by the close correlation relationships between the indices of the lipid peroxidation and apoptosis on the stages of the cryopreservation process. Medical and social effect. Medicine. Product Description popup.authors Аношина М.Ю. Балан В.В. Калиниченко Т.О. Мінченко Ж.М. Мироненко Г.А. Павлюк Р.П. popup.nrat_date 2020-04-02 Close