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Information × Registration Number 0216U008212, 0115U000310 , R & D reports Title Evaluating of the efficiency of home intravenous immunoglobulin and study its influence on the haemostasis system in lymphoproliferative neoplasias. popup.stage_title Head Timchenko A.S., Registration Date 15-12-2016 Organization Kiev Research Institute of Haematolojy and Blood Transfusion popup.description2 Object of research - the serum and blood plasma of patients with lymphoproliferative neoplasms (LPN); serum and blood plasma of practically healthy persons(donors); preparate of home intravenous immunoglobulin (IVIG) "Bioven-mono" (pharmaceutical factory" Biopharma " Ltd.). Aim of research -. to determine the hemostatic potential of the blood of patients with LPN during therapy native IVIG. Methods of research -. clinical, morphological, immunological, immunochemical, biochemistry, statistics. A general clinical research, as well as to determine the content of the main classes of immunoglobulins (IgG, IgA, IgM), and hemostatic parameters prior to chemotherapy (baseline parameters), before and after IVIG therapy (six patients with LPN). It is shown the patients (40 persons) with LPN have a wide range of differences of initial indicators of the main classes of Ig content in serum, as well as indicators of the hemostatic system. The use of IVIG "Bioven-mono" in a dose of 0.2 g / kg body weight significantly increased the level of IgG in serum blood and did not cause any significant changes in the hemostasis indices as compared to the data prior to immunotherapy. In addition, we studied the content of the main classes of immunoglobulins and the extent of the home drug purity "Bioven-mono" to be used for immunotherapy of patients with LPN. It was established that two of the five lots of the drug contained ballast proteins, and elevated levels of IgA and IgM. A cytogenetic study of 23 patients with B-CLL and it is shown that the presence of both quantitative s structural abnormalities of chromosomes may indicate that the multi-level mechanism of abnormal karyotype formation at the time of CLL diagnosis. Branch of application - medicine. Medical and social effect. Product Description popup.authors Бурнаєва С.В. Вергун Л.Ю. Корець К.В. Сівкович С.О. Сергутіна С.Ю. popup.nrat_date 2020-04-02 Close