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Information × Registration Number 0216U010287, 0115U004564 , R & D reports Title Physico-chemical mechanisms of the spontaneous point mutations: a model quantum-chemical investigation popup.stage_title Head Brovarets' Ol'ha Oleksandrivna, Registration Date 27-12-2016 Organization Institute of Molecular Biology and Genetics of NASU popup.description2 At the MP2/cc-pVQZ//B3LYP/6-311++G(d,p) level of theory it was shown for the first time that pairs of nucleotide bases with Watson-Crick architecture of the H-bonding - classic, long, short, one or both monomers of which are in the basic or rare tautomeric forms, - stay in the slow (in comparison with the time, that high-fidelity DNA-polymerase spends on the incorporation into the DNA double helix of one nucleotide) tautomeric equilibrium with the corresponding wobble pairs. Tautomerisation of each base pair proceeds via four topologically and energetically non-equivalent pathways through the zwitterionic transition states - H-bonded pairs of protonated and deprotonated bases. Product Description popup.authors Броварець Ольга Олександрівна Говорун Дмитро Миколайович popup.nrat_date 2020-04-02 Close