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Information × Registration Number 0216U010297, 0112U002657 , R & D reports Title Development of methods of synthesis, research of properties and mechanisms of action of new potentially bioactive compounds. popup.stage_title Head Kukhar V., Registration Date 29-12-2016 Organization Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine popup.description2 Preparative methods were developed and new functionally substituted azoles, azines and their condensed derivatives The biological activity of synthesized azaheterocycles was investigated, the relationship between activity was established and compounds with high antitumor, antimicrobial activity and vasoactivity were revealed. New organocatalysts were created and methods influencing on a stereo - and enantioselectivity of compounds were developed. A new set of evaluation functions H1, H2 and RFL, which are based on the evaluation function AutoDock, AutoDock Vina and RF-score, inhibition constants for calculations and forecasting activity of synthetic organic compounds was created. The participation of phosphatidylcholine-hydrolyzing phospholipase C in the production of the lipid second messengers, in the implementation of the intracellular action of jasmonic acid and the formation of plant resistance to biotic stress was revealed. Eco-friendly composite products based on colloidal solutions of zinc, manganese and cobalt were created and their bioactivity was defined.5481 Product Description popup.authors А.І. Вовк В.С. Броварець В.С. Кравець М.Д. Аксиленко О.І. Колодяжний О.Б. Смолій Т.В.Осадчук popup.nrat_date 2020-04-02 Close