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Information × Registration Number 0216U010306, 0116U002802 , R & D reports Title Fluorocontaining analogs of glutamate and -aminobutyric acid: synthesis and analysis of modulated influence on the transport of the neurotransmitters in nerve terminals of the brain. popup.stage_title Head Kukhar V.P., Registration Date 29-12-2016 Organization Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine popup.description2 The synthetic methods of new fluorine-substituted stereoisomers of glutamate and glutamine were developed with the substituents such as C3F7, CF3, in diastereomeric mixture and diastereomeric pure forms. It is found, the stereoisomer of the glutamate №6 with the substituent CF3 is able to decrease the initial velocity of L-[14C]glutamate uptake by synaptosomes of the rats. Fluorine-substituted analogs f glutamate (№7, №8, №9, №11) do not influenced on sodium-depended accumulation and on Са2+-independent L-[14C]glutamate uptake by synaptosomes of the rats.5481 Product Description popup.authors І. І. Герус К. В. Тарасенко Н.Г. Позднякова Т.О. Борисова popup.nrat_date 2020-04-02 Close
R & D report
Fluorocontaining analogs of glutamate and -aminobutyric acid: synthesis and analysis of modulated influence on the transport of the neurotransmitters in nerve terminals of the brain.
Head: Kukhar V.P.. Fluorocontaining analogs of glutamate and -aminobutyric acid: synthesis and analysis of modulated influence on the transport of the neurotransmitters in nerve terminals of the brain.. (popup.stage: ). Institute of Bioorganic Chemistry and Petrochemistry of National Academy of Sciences of Ukraine. № 0216U010306
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Updated: 2026-03-21


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