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Information × Registration Number 0216U990182, 0113U007322 , R & D reports Title The development of an inactivated vaccine against pasteurellosis using a epizootic actual serovars pathogens popup.stage_title Head Gadzevych Dmitriy Viktorivich, Кандидат ветеринарних наук Registration Date 22-01-2016 Organization Nationali Scientific Center "Institute of Experimental and Clinical Veterinary Medicine" popup.description2 The object of study - culture, biochemical, antigenic and immunogenic properties of the strains, antigens, manufacturing technology. As a result of the epizootological monitoring of animal diseases bacterial etiology was studied epizootic situation of pasteurellosis in 38 farms in the central and south-eastern regions of Ukraine, the Museum of strains of laboratory was replenished 4 epizootic cultures of Pasteurella, were developed and approved guidelines "Pasteurellosis animals (epizootiology, diagnosis and Immunization). For the production and control of inactivated vaccine against pasteurellosis animals have been developed production regulations. Using the three strains of Pasteurella multocida and two strains of Pasteurella haemolytica, it had stable biological, expressed antigenic (antibody levels of 1: 256 to 1: 512 log2) and immunogenic properties (ID50 of 0.324 to 0.487 billion cell) was made experimental series inactivated a vaccine against pasteurellosis animals. As a result of studying the immune-biological properties of the vaccine on animals has been established its safety and high protective, antigenic activity (protection of vaccinated animals after infection been more 80%, the level of specific antibody titers in the serum of the immunized groups of animals was by of 7,9 to 11,5 log2). Application of the vaccine to activate the immune response in animals. On day 28 after vaccination, the vaccinated animals were statistically significant (P<0.05) increase in the amount of immunoglobulin M and G. Product Description popup.authors Гадзевич Ольга Вікторівна Кривогіна Тетяна Василівна Чебанюк Ірина Владиславівна popup.nrat_date 2020-04-02 Close