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Registration Number

0217U000006, 0115U000251 , R & D reports

Title

Determine the role of T-helper 17 type in the formation of systemic inflammation in patients with the chronic obstructive lung disease

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Head

Rekalova Elena Myhaylovna,

Registration Date

05-01-2017

Organization

Institute of tuberculosis and pulmonology named by F. G. Yanovsky

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Object - peripheral blood of 45 patients with chronic obstructive pulmonary disease (COPD) in remission, 23 patients with chronic bronchitis (CB) in remission, 17 healthy ipersons. Aim - to clarify the role of T-helper type 17 in the pathogenesis of chronic obstructive pulmonary disease and their participation in the formation of systemic inflammation in patients with this disease. Methods - clinical, immunological, statistics. It has been found that patients with COPD in remission there are of systemic immune imbalance (quantitative and functional changes in immune cells with activation of T-helper 1, 2 and 17 types). The relation of T-helper type 17 with features of immune responses and level of biologically active substances in patients with COPD was observed. Elevated level of IL-17A associated with ongoing active inflammation (leukocytosis, neutrophilocytosis, activation of B-lymphocytes and natural killer cells, increased the levels of IL-8 and C-reactive protein in serum). It is established that the IL17A production increases as the disease progresses (higher in patients with severe COPD and maximum worsening of respiratory function) and depends on the frequency of exacerbations in a year (raises in process of their increase). In patients with chronic bronchitis at remission stage do not found connection of T-helper type 17 with features of immune responses and level of biologically active substances (monocytophenia, inhibition of the functional activity of T-helper cells, activation of B- and phagocytic links of immunity). A technology for the detection of inflammatory activity in patients with COPD and chronic bronchitis, which is to determine of the IL-17A and C-RP levels in the serum of patients has been developed. Increased IL17A level to 1.2 times or higher and C-RP to1.7 times or higher with respect to these parameters in patients with chronic bronchitis are markers of inflammatory activity. A developed "Method for determining the activity of the inflammatory process in patients with chronic obstructive pulmonary disease", which allows increasing accuracy of determining the activity of the inflammatory process by 35.5%. Sphere of application - immunolody, pulmonology

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Грабченко Наталія Іванівна
Коваль Наталя Григорівна
Козачук Ірина Анатолівна
Кулик Микола Іванович
Матвієнко Юлія Олександрівна
Панасюкова Оксана Романівна
Панащук Ігор Олексійович
Рекалова Олена Михайлівна
Сінгаєвський Мирослав Богданович
Ясирь Світлана Григоівна

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2020-04-02