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Information × Registration Number 0217U000435, 0115U002701 , R & D reports Title Justification methods of correction of endothelial dysfunction and emotional state disorders in children, residents of radioactively contaminated areas, and children who are displaced from the southeast Ukraine popup.stage_title Head Stepanova Yevgeniya Ivanovna., Доктор медичних наук Registration Date 03-02-2017 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 The object of study: children - residents of contaminated territories and children displaced from the area of ??the ATO. Objective: To determine the means - donator NO, are able to replenish the reserve of L-arginine and an assessment of their effectiveness for the correction of endothelial dysfunction in children, residents of contaminated territories. To assess the efficacy of ARV therapy for correction of psycho-emotional state of children displaced from the south-east of Ukraine. Methods: clinical, laboratory, tools, statistics. The results and their novelty. According to selective screening selected group of children - residents of contaminated areas with the presence of clinical and para-clinical signs of endothelial dysfunction. In children with endothelial dysfunction, which in addition to basic therapy course donator NO - L-arginine experienced pronounced positive effect, good tolerability, no side effects. Study of nitric oxide in the system dynamics use L-arginine found in children with endothelial dysfunction increase in serum arginine, nitrite, nitrate, sum NO metabolites. After the application of L-arginine was an increase in permeability of the peripheral bronchi and eliminating bronchospasm. Decrease the intensity of lipid peroxidation - a reduction of serum lipid peroxidation products reacting with thiobarbituric acid, with increased antioxidant activity - catalase. Thermographic study endothelium-dependent reactions of small vessels occlusion in the dynamics of the use of L-arginine showed increase of parameters overcompensation circulation period. Estimation of the endothelium-dependent vasodilation of the large vessels using the method of ultrasonic imaging of the lumen of the brachial artery showed an increase in the diameter of the brachial artery and its growth in a sample postoklyuziynoy reactive hyperemia after applying the rate of L-arginine. This indicates an increase in endothelial vasomotor capacity. In the dynamics of the use of L-arginine was determined by the tendency to improve myocardial repolarization processes. No marked change in autonomic regulation of the heart rhythm. Addition of L-arginine to the basic therapy increased the relative number of T-lymphocytes, and to normalize their subpopulation composition. The use of art - therapy for children displaced from the war zone in the south-east of Ukraine showed a decrease in the frequency of anxiety, exhaustion and aggression, which helped to improve their mental and emotional state. Product Description popup.authors Боярский Володимир Георгієвич Вдовенко Віталій Юрійович Гриценко Тетяна Володимирівна Зігало Віктор Миколайович Колпаков Ігор Евгенович Кондрашова Валентина Григорівна Леонович Олена Семенівна Литвинець Оксана Михалівна Позниш Вікторія Анатоліївна popup.nrat_date 2020-04-02 Close