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Information × Registration Number 0217U000438, 0116U003570 , R & D reports Title Identification of clinical and functional peculiarities of the non-cancerous endocrine disease course in persons exposed to ionizing radiation after the Choprnobyl accident and optimization of diagnostics and correction of the revealed disorders popup.stage_title Head Kaminsky Oleksij Valentinovich, Доктор медичних наук Registration Date 03-02-2017 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 Object of study - a retrospective assessment of clinical data on the state of the central and peripheral parts of the endocrine system in adults exposed as a result of the Chernobyl accident at a young age, and their descendants. The average external dose was 0.187 Gy for adults, thyroid doses in children were within 0.1-1.55 Gy. The verified clinical data were received by examination of persons in outpatient or inpatient setting. The objective of research - to study the incidence and structure of endocrine diseases in adults and children affected by the Chernobyl accident. Methods: the generally accepted clinical, anthropometric (weight, height, body mass index), instrumental (blood pressure, ECG, thyroid and parathyroid ultrasound), laboratory (biochemical, hormonal), statistical. A retrospective evaluation of the clinical data on the state of the endocrine system in 13,158 clean-up workers of the Chernobyl NPP accident exposed at a young age (10-30 years old at the time of the accident). A retrospective and prospective assessment of 579 patients with endocrine pathology was held in the clinical setting in the remote terms of the Chernobyl accident. A unified study card was elaborated with taking into account the peculiarities of possible non-cancerous endocrine disease in those exposed as a result of the Chernobyl accident at a young age. The age-related peculiarities of non-malignant diseases of the endocrine system were revealed among liquidators exposed at a young age, consisting in the presence of an increased risk of type 2 diabetes mellitus among young liquidators and persons exposed to ionizing radiation in the age of 10-30 years. This risk was almost twice as large than in unexposed individuals with the metabolic syndrome because of the lack of a clear trend in risk of fatal cardiovascular events and a similar contribution to non-radiation factors. At the same time the frequency of thyroid disease (diffuse goiter, hypothyroidism) was significantly higher. It was determined that children born to parents survived after the Chernobyl accident, in the critical age period, namely - in the period of pubertal development, have structural and functional changes in the thyroid system, which may be early manifestations of pathological processes with the possibility of transformation in the direction of manifestation of disease in the future in the form of chronic autoimmune thyroiditis, nodular goiter and hypothyroidism. Implementation - 32 scientific papers and 3 articles published, 29 abstracts of conferences issued, 31 reports made at conferences. Scope of application - radiation medicine, clinical endocrinology. Product Description popup.authors Єгорова Ірина Вікторівна Афанасьєв Дмитро Євгенович Камінський Олексій Валентинович Копилова Ольга Василівна Муравйова Ірина Миколаїна Пронін Олексій Володимирович Чикалова Ірина Григорівна Яніна Антоніна Миколаївна popup.nrat_date 2020-04-02 Close