Updated: 2025-12-07
Total number
Full text
Total number
Full text
Number of local repositories
Full text
0217U000438, 0116U003570 , R & D reports
Identification of clinical and functional peculiarities of the non-cancerous endocrine disease course in persons exposed to ionizing radiation after the Choprnobyl accident and optimization of diagnostics and correction of the revealed disorders
Kaminsky Oleksij Valentinovich, Доктор медичних наук
03-02-2017
State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine "
Object of study - a retrospective assessment of clinical data on the state of the central and peripheral parts of the endocrine system in adults exposed as a result of the Chernobyl accident at a young age, and their descendants. The average external dose was 0.187 Gy for adults, thyroid doses in children were within 0.1-1.55 Gy. The verified clinical data were received by examination of persons in outpatient or inpatient setting. The objective of research - to study the incidence and structure of endocrine diseases in adults and children affected by the Chernobyl accident. Methods: the generally accepted clinical, anthropometric (weight, height, body mass index), instrumental (blood pressure, ECG, thyroid and parathyroid ultrasound), laboratory (biochemical, hormonal), statistical. A retrospective evaluation of the clinical data on the state of the endocrine system in 13,158 clean-up workers of the Chernobyl NPP accident exposed at a young age (10-30 years old at the time of the accident). A retrospective and prospective assessment of 579 patients with endocrine pathology was held in the clinical setting in the remote terms of the Chernobyl accident. A unified study card was elaborated with taking into account the peculiarities of possible non-cancerous endocrine disease in those exposed as a result of the Chernobyl accident at a young age. The age-related peculiarities of non-malignant diseases of the endocrine system were revealed among liquidators exposed at a young age, consisting in the presence of an increased risk of type 2 diabetes mellitus among young liquidators and persons exposed to ionizing radiation in the age of 10-30 years. This risk was almost twice as large than in unexposed individuals with the metabolic syndrome because of the lack of a clear trend in risk of fatal cardiovascular events and a similar contribution to non-radiation factors. At the same time the frequency of thyroid disease (diffuse goiter, hypothyroidism) was significantly higher. It was determined that children born to parents survived after the Chernobyl accident, in the critical age period, namely - in the period of pubertal development, have structural and functional changes in the thyroid system, which may be early manifestations of pathological processes with the possibility of transformation in the direction of manifestation of disease in the future in the form of chronic autoimmune thyroiditis, nodular goiter and hypothyroidism. Implementation - 32 scientific papers and 3 articles published, 29 abstracts of conferences issued, 31 reports made at conferences. Scope of application - radiation medicine, clinical endocrinology.
Єгорова Ірина Вікторівна
Афанасьєв Дмитро Євгенович
Камінський Олексій Валентинович
Копилова Ольга Василівна
Муравйова Ірина Миколаїна
Пронін Олексій Володимирович
Чикалова Ірина Григорівна
Яніна Антоніна Миколаївна
2020-04-02
Updated: 2025-12-07
Saving a scientific data set occurs in two stages:
1.) Creating a data set
Enter the name of the set, a brief description of the set (annotation), and click the “Create set” button. After that, a draft data set will be automatically created, which you can save for further work with the set. The system will redirect you to the “Data set information” page.
2.) Filling in the data
On the “Data set information” page, you need to fill in all the fields related to the data set and upload the files.
Please note! Each file is uploaded separately. This is done to ensure the stable operation of the system.
Once you have filled in the information about the scientific data set and added the necessary files, you can save the draft or send the data to the system.
Please note! Once the data has been sent, you cannot change it.
Drafts are necessary for storing the data set and editing it before sending.
All accounts on the NRA website go through a standard registration procedure and are verified. However, in order to obtain additional features, such as publishing open reviews of academic texts, verification by affiliation is required.
To obtain the status “verified”, you must change your primary email address to a corporate one, which is tied to a scientific or educational institution.
For example: user@ukrintei.ua, user@nas.gov.ua
After confirming your corporate email address, your account will be automatically verified by affiliation.
If your email address is corporate, but your account does not have a verification mark, you need to write to us at the email address NRAT@ukrintei.ua. After verification, we will add your address to the database, and your account will be verified.
After completing the verification procedure for affiliation, you can change the primary email address to a convenient one for you, without losing your status during the current verification.
You only need to verify for affiliation once.
* We use corporate addresses from the Unified State Database on Education and the State Register of Scientific Institutions Supported by the State
To search for news published on the official website of NRАT in the “News” section, you need to enter one word, several words, or an exact phrase in the search field. Different terms are separated by spaces.
The search is performed everywhere – in the title and the news text.
For a more comprehensive result, it is recommended to use word stems (parts of words without endings).
When using multiple words for the search, they are combined using one of the logical methods described below.
By default, the logical connector “and” is used. In this case, search results will include all news releases that contain the specified words, even if they are located separately from each other and are in different parts of the text.
Example: Search phrase: OECD report. Search result: all news containing the words “report” and “OECD” in the text and in the title, both together and separately.
If a phrase or phrase is enclosed in quotation marks (“), the results will include all publications where this exact phrase or phrase is found.
Example: Search phrase: “OECD report.” Search result: all news containing the exact phrase “OECD report.”
If you know the publication date of the news or are interested in a specific time frame in which they were published on the website, you can select such a date or date range in the additional field that looks like a calendar. The date is entered in the format year-month-day and confirmed by clicking on the corresponding date in the calendar dropdown. You can enter a date or choose one by browsing through the calendar by months and years. By default, the interval starts from the oldest date (2018-01-23) and ends with the current date.
You can also use one or more hashtags, which are located under the search field on the right side of the “News” page.
Please note: The search for academic texts is carried out in a separate search window at the following link https://nrat.ukrintei.ua/searchdb.