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0217U000440,
0116U003572
,
Neyropsyсhobiological mechanisms of the mood and cognitive disorders in the exposed persons as a result of the Chernobyl disaster considering polymorphisms of genes.
Loganovsky Konstantin,
03-02-2017
State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine "
The object of study: neuropsychiatric features and peripheral blood leukocytes of 65 liquidators of the Chernobyl, 26 persons exposed in utero, 21 unexposed. The goal - to explore the prospective neuropsychiatric features and identify relevant gene polymorphisms for affective and cognitive disorders distant period after exposure to ionizing radiation. Methods: The clinical neuropsychological, psychometric, cell, molecular, random. At the liquidators of the Chernobyl found cognitive decline to an average level of mild cognitive deficit MMSE criteria. Psychometric studies (BPRS, IES, IDA, GHQ-28, SDS) showed greater severity of psychopathology, compared with a group of internal control: higher levels of depression, somatoform disorders, anxiety / insomnia and social dysfunction. Determine the most relevant gene polymorphisms for affective (SLC6A4) and cognitive (APOE) disorders distant period after exposure to ionizing radiation to the specific epigeneticheskih factors (radiation factor, stress). In prenatally exposed individuals confirmed a specific neurocognitive deficits, which consists in maintaining a child diagnosed disharmony due to the relative decrease in verbal intelligence in comparison with the relative increase in non-verbal, which may reflect a violation of neurodevelopmental dominant hemisphere of the brain. Specific exposed in utero to the spatial deformation of amplitude-time parameters of early and late components of the auditory cognitive evoked potentials may indicate a violation of information and cognitive processes in the brain. Publications - 10 scientific papers, 16 reports at international conferences.
Абраменко Ірина Вікторівна
Антипчук Катерина Юріївна
Білоус Н.І.
Бомко Марія Олександрівна
Гресько М.В.
Колосинська О.О.
Крейніс Г.Ю.
Куц К.В.
Логановська Тетяна Костянтинівна
Масюк С.В.
Перчук І.В.
Чумак Станіслав Анатолійович
2020-04-02
Updated: 2025-12-07
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