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Information × Registration Number 0217U000441, 0116U003573 , R & D reports Title The study of association of radiation-induced changes in gene expression with non-cancer effects of the late period after exposure in Chornobyl clean-up workers. popup.stage_title Head Bazyka D., Доктор медичних наук Registration Date 03-02-2017 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 The object of study: peripheral blood lymphocytes of 50 Chornobyl clean-up workers and 20 persons of external control. Objective: to determine the quantitative characteristics of genetic and immunological parameters depending on the dose and age in lymphocytes of peripheral blood in Chornobyl clean up workers with chronic non-cancer diseases. Methods: immunological, genomic, cultural. In the late period after exposure an over-expression was identified of pro-apoptotic genes TP53, TP53I3, FASL and BAX, shown a link between FASLG gene expression and immunological violations; a tendency was established in increase of phosphorylated form of H2AX histone expression, reducing the CCND1gene expression and trends to increase the expression of cytoplasmic Cyclin D1 protein at doses above 500 mSv; shown telomere length shortening in lymphocytes and changes of genomic regulation of telomere-telomerase complex. Product Description popup.authors Ільєнко Ірина Миколаївна Бєляєв Олег Анатолійович Бєляєва Надія Володимирівна Голярник Наталія Анатоліївна Домбровська Наталія Сергіївна Лясківська Олена Вікторівня Мазніченко Оксана Леонідівна Музалевська Катерина Дмитрівна popup.nrat_date 2020-04-02 Close