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Information × Registration Number 0217U000444, 0116U003576 , R & D reports Title The definition of gender peculiarities of the most common diseases of the circulatory system in participants of the accident at the Chernobyl nuclear power plant taking in account structural and functional changes in the myocardium, rs966221 polymorphism of the gene PDE4D and action of the radiation factor popup.stage_title Head Belyi David, Abramenko Irina, Registration Date 03-02-2017 Organization State institution "National research centеr for radiation medicine of the National academy of medical sciences of Ukraine " popup.description2 It was established the representative sample of Chernobyl NPP clean-up workers (CW) and non-irradiated persons (control group - CG) of both sexes suffered from the most common cardiovascular diseases (CVD). A retrospective and current analysis of case histories of CW admitted to the cardiology department in the 1986-2016 was done and their frequently CVD was determined. They included essential hypertension (EH) and coronary heart disease (CHD). The men from CW group and CG developed EH on 6.5 and 5.7 years earlier CHD. In women, this period was even longer - 10.7 and 9.7 years, respectively. Men from CW group got EH being on average 5 years younger compared with patients of both sexes from CG. In the period from the beginning of the Chernobyl accident to the present day men from CG group developed CHD on 3.3 and 5.6 years earlier than women from CW group and men of CG respectively. EH was diagnosed in men from CW on average on seven and in women from CW on 4 years earlier the corresponding control. Almost a third of patients had a combination of three risk factors (RF), besides in women CW proportion of patients was significantly more than in men of CW and CG. Compared with men, women frequently demonstrated arterial hypertension preceding the development of CHD, and obesity. In women it was registered the decrease of parasympathetic regulation physiological influence on heart rate, while growth of VLFp-component in the overall power range was set that characterizes increased neurohumoral activity and metabolic disorders. The largest contribution to the reduction of heart rate variability sympathicotonia mainly leads in males together with significant decrease in parasympathetic activity, in females it is the reduce of vagal influence on heart rate. In women after myocardial infarction the duration of ischemia per day and it any episode was higher than the same data in men in 2.7 and 3.1 times, but in women with angina less for 60.6% and 64.5%. In women under follow-up examination, the relative thickness of the left ventricle wall was significantly greater than in men. Hypertrophy of posterior wall of the left ventricle (LV) dominated in men (LV) and interventricular septum in women. Mean left ventricular myocardial mass and its index in men was significantly higher than in women. The number of LV hypertrophy cases in women with obesity of 2-3 grade from CW group was in 3.2 times more than in men from CW (p <0.001), whereas in CG such difference was negligible. Male CW had 3.4 % lower ejection fraction than that of women (p = 0.004). Product Description popup.authors Абраменко І.В. Білий Д.О. Базика О.Д. Ковальов О.С. Круглова В.О. Курсіна Н.В. Макаревич О.М. Настіна О.М. Плескач Г.В. Садова С.В. Сидоренко Г.В. popup.nrat_date 2020-04-02 Close