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Information × Registration Number 0217U000480, 0116U000176 , R & D reports Title Determination of the complex of prognostic factors for disease course evaluation and treatment strategy stratification in patients with chronic lymphocytic leukemia. popup.stage_title Head Maslyak Zvenyslava Volodymyrivna, Registration Date 06-02-2017 Organization LVIV RESEARCH INSTITUTE OF BLOOD PATHOLOGY AND TRANSFUSIONAL MEDICINE popup.description2 Research work report: 118 pages, 20 tab., 10 fig., 113 ref., 3 addendums. Objects of the study - group of 207 patients with B-cell lymphoid neoplasms including 155 patients with chronic lymphocytic leukemia (CLL) and 52 patients with non-Hodgkin's lymphoma (NHL); malignant cells, blood serum, bone marrow. Aim of the study: determination of the complex of prognostic factors for chronic lymphocytic leukemia disease course with the purpose of further treatment strategy stratification depending on the individual features of the patient. Methods of investigations: clinical, cytological, histological, immunophenotypic, cytogenetic, radiometric and immunoenzymatic investigations and statistical analysis. Frequency, clinical and hematological symptoms, course of the disease, morphological features, immunophenotypic signs of the tumor malignant cells were determined. Clinical and laboratory risk factors for thrombosis and their prognostic significance in CLL were studied. It was revealed that significant proportion of elderly patients who had their diagnosis made at the early stages of disease remained in good condition and did not require treatment during the observation period (2-20 years). In this group treatment with short cycles of chlorambucil led to partial response. As to the more aggressive therapies like FC and BR schemes - they are more effective as compared to chlorambucil monotherapy and may be applied in elderly patients who show adequate renal function and do not have significant comorbidities. It was shown that systemic inflammation markers, namely increased levels of IL-6, TNF and ESR were detected in 88.9% of NHL/CLL patients. Activity of systemic inflamation grew higher along with NHL/CLL disease progression. The obtained data indicates a close connection between systemic inflamation, hypercoagulation and thrombosis. It was found that increased levels of SFMC and/or D-dimer as well as shortened aPTT which were detected in 68,9% of the patients with NHL/CLL indicated the high risk for thrombosis development in patients with mature B-cell lymphoid neoplasms. These markers of hypercoagulation were associated with disease progression according to correlations between SFMC level and disease stage and between aPTT and the level of beta-2-microglobulin. They were also associated with poor prognosis according to relations between SFMC and D-dimer levels and international prognostic index IPI respectively. Disorders of the lipid metabolism may potentiate development of hypercoagulation and systemic inflamation therefore increasing risk of thrombosis in patients with NHL/CLL. Results of this study will be implemented in the practical activity of Hematology Department of the Lviv City Hospital Product Description popup.authors Іваник Соломія Львівна Барілка Віра Анатолієвна Ванько Ірина Степанівна Виговська Ольга Ярославівна Даниш Ольга Йосипівна Дзісь Євген Іванович Лебедь Галина Богданівна Логінський Володимир Євстахович Лук"янова Анна Сергіївна Лукавецький Лесь Миронович Матлан Володимир Львович Мельник Марія Іллярівна Пеленьо Наталія Володимирівна Римар Марія Михайлівна Сусіда Христина Романівна Цяпка Орест Миколайович Шалай Ольга Олексіївна Юрчишак Ірина Михайлівна Ясниський Зеновій Ількович popup.nrat_date 2020-04-02 Close