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Information × Registration Number 0217U000505, 0114U001204 , R & D reports Title The determination of the pleiotropic effect of the camphoric acid's derivate - spermatogenesis stimulator popup.stage_title Head Kudrya Maria Yakivna, Кандидат біологічних наук Registration Date 08-02-2017 Organization State Institution "V. Danilevsky Institute for Endocrine Pathology Problems National Academy of Medical Sciences of Ukraine" popup.description2 Objects of research - the substance and the oral dosage form camphor derivative acid functional-metabolic state of the liver. The aim - to study the effect of camphor derivative acid - katiazin in functional and metabolic liver induced damaging factors are different genesis. Methods - pharmacological, toxicological, biochemical, physiological, organic synthesis, spectral, physico-chemical, pharmaceutical and technology, statistics. The composition and technology of oral dosage forms of camphor derivative acids in capsule form. For analytical, pharmaceutical, technological and biological research drafted substance and dosage form. Farm studied technological and microbiological characteristics capsules 'Katiazin' covered by the DF Ukraine 2 ed. The criteria of quality assessment capsules 'Katiazin' 0.01 g proposed methods of qualitative and quantitative analysis as capsules 'Katiazin'. Played three models subchronic toxic hepatitis, tetrachloro-metan-, paratsetamol- induced and combined (paracetamol + ethanol) to study the impact of substance and oral dosage forms of camphor derivative acid functional disorders of the liver. Found that regardless of origins hepatotoxicants, camphor acid derivative in the form of substance (10 and 50 mg / kg bw) and oral dosage form (active substance content of 10 mg) to normalize the enzymatic activity of des intoxication improve liver function, restoration of functional activity hepatocyte preservation pro-antioxidant balance is showing signs of anticoagulant action, normalizing semen parameters positively affect the repair processes in the liver. Areas of application - pharmaceuticals, chemical and pharmaceutical industry. Product Description popup.authors Бойко М. Бурма Т. Вакула В. Гавриш Т. Завадська Н. Карпова Т. Козар В. Кравченко С. Кудря М. Кустова С. Лалименко О. Матвєєва Т. Мельниківська Н Нікішина Л. Палагіна. І. Свидло І. Селюкова Н. Сергієнко Л. Устенко Н. Яременко Ф. popup.nrat_date 2020-04-02 Close