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Information × Registration Number 0217U000508, 0114U001205 , R & D reports Title Set features of hormonal-metabolic and immunological disorders in patients with type 2 diabetes mellitus and obesity with non-alcoholic fatty liver disease popup.stage_title Head Kravtchun Nonna Alexsandrovna, Registration Date 08-02-2017 Organization State Institution "V. Danilevsky Institute for Endocrine Pathology Problems National Academy of Medical Sciences of Ukraine" popup.description2 Object of study - metabolic, immunological, hormonal and psycho-emotional state of patients with diabetes mellitus (DM) type 2 with nonalcoholic fatty liver disease (NAFLD) and adiponectin gene polymorphism and tumor necrosis factor-alfa (TNF-alfa) in patients with type 2 type of NAFLD and control groups. The aim - to develop pathogenetically grounded algorithms for diagnosis and treatment of patients with type 2 diabetes in the presence of nonalcoholic fatty liver disease. Research methods - clinical, biochemical, immunological, tools, molecular-genetic. The levels of 8-izoprostoglandyn, leptin, interleukin-6 (IL-6), resistin, ceruloplasmin, adiponectin in patients with type 2 diabetes, obesity and related NAFLD. Established relationships severity of alexithymia with metabolic disorders in patients with type 2 diabetes if NAFLD. Dedicated markers of progression of diabetic nephropathy (DN) in patients with type 2 diabetes in combination with NAFLD. The dependence between the stages of fibrosis, endothelial dysfunction indicators (homocysteine and albuminuria) and cellular immunity and levels of melatonin excretion in urine. In patients with type 2 diabetes NAFLD set of features infarction ventricular remodeling by type of hypertrophy and diastolic dysfunction. Developed dietary recommendations for patients with type 2 diabetes NAFLD taking into account ethnic characteristics and average daily rates of consumption of end products of glycating (CPG). Hepatoprotectors shown clinical efficacy of different groups. The investigated single-nucleotide polymorphism gene factor TNF-alfa in patients with type 2 diabetes in the presence and absence NAFLD, provided macro / microvascular complications. Mathematical models for risk assessment of NAFLD in patients with type 2 diabetes. Product Description popup.authors Алексеєва І. Атраментова Л. Бурма Т. Гавриш Т. Гладких О. Гончарова О. Дорош О. Завадська Н. Земляніцина О. Кравчун Н. Красова Н. Лещенко Ж. Олійникова С. Полозова Л. Полторак В. Романова І. Селюкова Н. Тижненко Т. Черняєва А. Чернявська І. popup.nrat_date 2020-04-02 Close